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Use in Pregnancy: Losartan Potassium: When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, Losartan Potassium should be discontinued as soon as possible.
Hydrochlorothiazide: Crosses the placenta and has reports of neonatal jaundice, thrombocytopenia, and electrolyte imbalances after maternal use. Reductions in maternal blood volume could also adversely affect placental perfusion.
Use in Lactation: Losartan Potassium is not known whether it is excreted in human milk. Hydrochlorothiazide may appear in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Large doses may suppress lactation.
